Our laboratory is dedicated to developing a high-throughput cryo-electron tomography (cryo-ET) pipeline for high-resolution structure determination of molecular machines in cells. Our state-of-the-art imaging system has been utilized to gain molecular insights into fundamental biochemical processes: bacterial motility, chemotactic signaling, protein secretion, and DNA translocation.
We are very grateful that our research projects are supported by NIGMS, NIAID, NIH, and Yale.
Cryo-Electron Tomography (cryo-ET) is one of the most advanced technologies to visualize molecular machines in situ. We aim to streamline a high-throughput cryo-ET pipeline for high resolution imaging of molecular machines and cells.
Interested candidates should have a Ph.D. in microbiology, biophysics or a related field. Please contact Dr. Liu along with CV, statement of research interests, and contact information for three references.
We are fortunate to have access to state-of-the-art cryo-ET facility at Yale West Campus, including cryo-CLEM, cryo-FIB and 300kV Krios
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