Visualizing Molecular Machines in Cells 

(Supported by NIH/NIAID/NIGMS and Yale University)

Our laboratory is dedicated to developing a high-throughput cryo-electron tomography (cryo-ET) pipeline for high-resolution structure determination of molecular machines in cells. Our state-of-the-art imaging system has been utilized to gain molecular insights into fundamental biochemical processes: bacterial motility, chemotactic signaling, protein secretion, and DNA translocation. 


Postdoctoral Positions available

Interested candidates should have a Ph.D. in microbiology, biophysics or a related field. Please contact Dr. Liu along with CV, statement of research interests, and contact information for three references.

Grant Supports

We are very grateful that our research projects are supported by NIGMS, NIAID, NIH, and Yale.


Journal Covers

High-throughput Cryo-Electron Tomography (Cryo-ET)​

Cryo-Electron Tomography (cryo-ET) is one of the most advanced technologies to visualize molecular machines in situ. We aim to streamline a high-throughput cryo-ET pipeline for high resolution imaging of molecular machines and cells. 

Electron Tomography at Yale University

State-of-the-art Cryo-ET facility at Yale University

We are fortunate to have access to state-of-the-art cryo-ET facility at Yale West Campus, including cryo-CLEM, cryo-FIB and 300kV Krios

What Inspires Us

Louis Armstrong: "What a Wonderful World".
Apple's "Think Different" commercial: "Here's to the Crazy Ones".

Steve Jobs' 2005 Stanford Commencement Address: "Stay Hungry, Stay Foolish".

​Charles Darwin: "It is not the strongest of the species that survives, nor the most intelligent that survives. It is the one that is the most adaptable to change."