The LIU lab

Electron Tomography at Yale University

FEI Titan KriOs 

Old NEWs at UTHealth

Grant Supports

We are very grateful that our research projects are supported by NIH, NIAID, NIGMS, and Welch Foundation.

Postdoctoral Positions available

Interested candidates should have a Ph.D. in microbiology, biophysics or a related field. Please contact Dr. Liu along with CV, statement of research interests, and contact information for three references.

(Supported by NIH/NIAID/NIGMS and Welch Foundation)

Our Inspiration

Louis Armstrong: "What a Wonderful World".

Apple's think different commercial "Here's to the Crazy Ones".

Steve Jobs' 2005 Stanford Commencement Address "Stay Hungry, Stay Foolish".

​Charles Darwin: "It is not the strongest of the species that survives, nor the most intelligent that survives. It is the one that is the most adaptable to change."

Cryo-ET Facility at Yale University

After working at UTHealth for 10 years, our laboratory will be relocated from Houston to Yale University in August 2017. We will be able to access state-of-the-art cryo-EM facilities including a new Titan Krios G2, a Gatan K2 Summit direct electron detector with GIF quantum energy filter, and phase plate.


journal covers

High-throughput Cyro-electron tomography (cryo-et)

Cryo-Electron Tomography (cryo-ET) is one of the most advanced technologies to visualize molecular machines in situ at molecular level. Our high-throughput cryo-ET pipeline enables us to determine in situ structure of the molecular machine in cells within a week. 

Our laboratory is dedicated to developing a high-throughput cryo-electron tomography (cryo-ET) pipeline for high-resolution structure determination of molecular machines in cells. Our state-of-the-art imaging system has been utilized to gain molecular insights into fundamental biochemical processes: bacterial motility, chemotactic signaling, protein secretion, and DNA translocation. 

visualizing molecular machines in cells