Electron Tomography at Yale University

Grant Supports

We are very grateful that our research projects are supported by NIH, NIAID, NIGMS, and Yale.

Our Inspiration

Louis Armstrong: "What a Wonderful World".

Apple's think different commercial "Here's to the Crazy Ones".

Steve Jobs' 2005 Stanford Commencement Address "Stay Hungry, Stay Foolish".

​Charles Darwin: "It is not the strongest of the species that survives, nor the most intelligent that survives. It is the one that is the most adaptable to change."

Cryo-ET Facility at Yale University

After working at UTHealth for 10 years, our laboratory was relocated from Houston to Yale University in August 2017. We can access state-of-the-art cryo-EM facilities including Titan Krios G2, Gatan K2 direct electron detector with GIF quantum energy filter, and phase plate.


journal covers

High-throughput Cyro-electron tomography (cryo-et)

Cryo-Electron Tomography (cryo-ET) is one of the most advanced technologies to visualize molecular machines in situ at molecular level. Our high-throughput cryo-ET pipeline enables us to determine in situ structure of the molecular machine in cells within a week. 

Our laboratory is dedicated to developing a high-throughput cryo-electron tomography (cryo-ET) pipeline for high-resolution structure determination of molecular machines in cells. Our state-of-the-art imaging system has been utilized to gain molecular insights into fundamental biochemical processes: bacterial motility, chemotactic signaling, protein secretion, and DNA translocation. 

visualizing molecular machines in cells 


Titan KriOs microscope at Yale is tuned up and ready to run !!!

(Supported by NIH/NIAID/NIGMS and Welch Foundation)

Old NEWs at UTHealth

Postdoctoral Positions available

Interested candidates should have a Ph.D. in microbiology, biophysics or a related field. Please contact Dr. Liu along with CV, statement of research interests, and contact information for three references.