Cryo-Electron Tomography (cryo-ET) is one of the most advanced technologies to visualize molecular machines in situ at molecular level. Our high-throughput cryo-ET pipeline enables us to determine in situ structure of the molecular machine in cells within a week.
Our laboratory is dedicated to developing a high-throughput cryo-electron tomography (cryo-ET) pipeline for high-resolution structure determination of molecular machines in cells. Our state-of-the-art imaging system has been utilized to gain molecular insights into fundamental biochemical processes: bacterial motility, chemotactic signaling, protein secretion, and DNA translocation.
1. Phage T7 Walks across bacterial surface.
2. Bacterial secretion system revealed in intact cell.
3. No grant writing, no funding support.
4. First McGovern Scholars recognized.
Interested candidates should have a Ph.D. in microbiology, biophysics or a related field. Please contact Dr. Liu along with CV, statement of research interests, and contact information for three references.
We are very grateful that our research projects are supported by NIH, NIAID, NIGMS, and Yale.
After working at UTHealth for 10 years, our laboratory was relocated from Houston to Yale University in August 2017. We can access state-of-the-art cryo-EM facilities including Titan Krios G2, Gatan K2 direct electron detector with GIF quantum energy filter, and phase plate.
Louis Armstrong: "What a Wonderful World".
Apple's think different commercial "Here's to the Crazy Ones".
Charles Darwin: "It is not the strongest of the species that survives, nor the most intelligent that survives. It is the one that is the most adaptable to change."