(coming in Spring 2017)
Interested candidates should have a Ph.D. in microbiology, biophysics or a related field. Please contact Dr. Liu along with CV, statement of research interests, and contact information for three references.
Cryo-Electron Tomography (cryo-ET) is one of the most exciting technologies to determine 3-D architecture of molecular machines in situ at molecular level. Our high-throughput cryo-ET pipeline provides unparalleled opportunities for visualizing the molecular machines in cells.
1. Phage T7 Walks across bacterial surface.
2. Bacterial secretion system revealed in intact cell.
3. No grant writing, no funding support.
4. First McGovern Scholars recognized.
We are very grateful that our research projects are supported by NIH, NIAID, NIGMS, and Welch Foundation.
We have a 300 kV Liquid Nitrogen cooled field-emission gun cryo-electron microscope (FEI Polara) and a direct electron detector (Gatan K2 Summit) at UTHealth. Together with advanced tomography packages (SerialEM, IMOD, TOMO3D and Protomo) implemented, our system is now able to achieve higher throughput and resolution. Our cutting-edge cryo-EM facility supports multiple NIH funded projects.In spring 2017, we will have a new Titan Krios G2 together with Gatan K2 Summit direct electron detector, GIF quantum energy filter, and phase plate.
Our laboratory is dedicated to developing a high-throughput cryo-electron tomography (cryo-ET) pipeline for high-resolution structure determination of molecular machines in cells. Our state-of-the-art imaging system has been utilized to gain molecular insights into fundamental biochemical processes: bacterial motility, chemotactic signaling, protein secretion, and DNA translocation.
The LIU lab
Electron Tomography at ut houston
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